MOTS-c: The Mitochondrial Regulator
The Maxoratide MOTS-c Peptide (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a premium research compound classified as a mitochondrial-derived peptide (MDP). It has attracted significant scientific interest in metabolic and energy regulation studies. Unlike most peptides encoded by nuclear DNA, MOTS-c is encoded directly within mitochondrial DNA.
This unique origin enables it to function as a key signaling molecule involved in regulating metabolic homeostasis and cellular energy communication. In scientific literature, it is often described as an “exercise mimetic” due to its ability to reproduce certain cellular adaptations associated with physical activity, without actual muscle contraction.
About MOTS-c Peptide
Mechanism of Action: AMPK Pathway Activation
Research primarily focuses on MOTS-c’s interaction with the folate-methionine cycle and its ability to activate the AMP-activated protein kinase (AMPK) pathway.
- Metabolic Flexibility: By stimulating AMPK signaling, MOTS-c is studied for its potential to enhance glucose uptake in skeletal muscle and improve insulin sensitivity in cellular models.
- Cellular Energy Regulation: It is implicated in mitochondrial biogenesis, supporting improved efficiency of cellular energy production.
- Fat Metabolism: Studies suggest it may influence lipid utilization by promoting lipolysis and encouraging the browning of adipose tissue, contributing to interest in obesity-related research models.
Research Applications & Storage
MOTS-c is supplied as a lyophilized white powder to ensure stability during transport and storage. For laboratory use, it should be reconstituted with bacteriostatic water under sterile conditions. Once prepared, the solution is sensitive to degradation and should be stored at 2–8°C, protected from direct light exposure.
Research Disclaimer
Maxoratide MOTS-c Peptide is intended strictly for in-vitro laboratory research and analytical purposes only. It is not approved for human consumption, diagnostic, or therapeutic use.
